Riesgo cardiovascular, adiposidad y marcadores aterogénicos e inflamatorios en pacientes con enfermedad metabólica.

Authors

DOI:

https://doi.org/10.58299/cisa.v5i5.41

Keywords:

Keywords Metabolic diseases, atherogenic index, adipokines, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, cardiovascular risk.

Abstract

Metabolic disorders are characterized by a low grade of chronic inflammation. Several inflammatory and atherogenic markers and adipokines are associated to metabolic syndrome and increase the atherosclerosis and cardiovascular morbidity and mortality. Objective: describe the cardiovascular risk, adiposity, atherogenic and inflammatory markers in Mexican patients from Durango State, Mexico. Anthropometric measurements, lipid profile, hematic biometry, and serum adipokines were made. Adiposity, atherogenic index, inflammation ratios, and cardiovascular risk were calculated. Corporal and visceral fat were classified as high and very high. Moreover, 88.3% of the patient met the criteria for Metabolic syndrome. Inflammation markers, atherogenic index, and cardiovascular risk were higher in patients with the highest number of comorbidities. Conclusion: the therapeutic target should be focused on correcting these abnormalities and decreasing CVR and mortality.

 

References

Akbas, E. M., Demirtas, L., Ozcicek, A., Timuroglu, A., Bakirci, E. M., Hamur, H., Ozcicek, F., & Turkmen, K. (2014). Association of epicardial adipose tissue, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with diabetic nephropathy. International Journal of Clinical and Experimental Medicine, 7(7), 1794–1801. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132146/

Bawadi, H., Katkhouda, R., Tayyem, R., Kerkadi, A., Bou Raad, S., & Subih, H. (2019). Abdominal fat is directly associated with inflammation in persons with Type-2 Diabetes regardless of glycemic control - A Jordanian Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 12, 2411–2417. https://doi.org/10.2147/DMSO.S214426

Bazyar, H., Adibmanesh, A., Javid, A.Z., Maghsoumi-Norouzabad, L., Gravand, E., Alipour, M., & Sadeghi, N. (2019). The relationship between metabolic factors and anthropometric indices with periodontal status in type 2 diabetes mellitus patients with chronic periodontitis. Obesity Medicine, 16, 100138. https://doi.org/10.1016/j.obmed.2019.100138

Bohra A. (2015). Oral Aspects of Metabolic Disorders. Journal of Metabolic Syndrome, 4(3):1–4. https://doi.org/10.4172/2167-0943.1000178

Borges, M. D., Franca, E. L., Fujimori, M., Silva, S. M. C., de Marchi, P. G. F., Deluque, A. L., Honorio-Franca, A. C., & de Abreu, L. C. (2018). Relationship between Proinflammatory Cytokines/Chemokines and Adipokines in Serum of Young Adults with Obesity. Endocrine, Metabolic & Immune Disorders-Drug Targets, 18(3), 260–267. https://doi.org/org/10.2174/1871530318666180131094733

Choi, J., Joseph, L., & Pilote, L. (2013). Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, 14(3), 232–244. https://doi.org/10.1111/obr.12003

Choy, P. C., Siow, Y. L., Mymin, D., & O, K. (2004). Lipids and atherosclerosis. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire, 82(1), 212–224. https://doi.org/10.1139/o03-085

Ellulu, M. S., Patimah, I., Khaza'ai, H., Rahmat, A., & Abed, Y. (2017). Obesity and inflammation: the linking mechanism and the complications. Archives of medical science: AMS, 13(4), 851–863. https://doi.org/10.5114/aoms.2016.58928

Evia-Viscarra, M. L., Rodea-Montero, E. R., Apolinar-Jiménez, E., & Quintana-Vargas, S. (2013). Metabolic syndrome and its components among obese (BMI >=95th) Mexican adolescents. Endocrine Connections, 2(4), 208–215. https://doi.org/10.1530/EC-13-0057

Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D'Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O'Donnell, C. J., Robinson, J. G., Schwartz, J. S., Shero, S. T., Smith, S. C., Sorlie, P., Stone, N. J., Wilson, P. W., Jordan, H. S., Nevo, L., Wnek, J. American College of Cardiology/American Heart Association Task Force on Practice Guidelines (2014). 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation, 129(25), S49–S73. https://doi.org/10.1161/01.cir.0000437741.48606.98

Horan, A. A., Albsoul-Younes, A., Kasabri, V., Suyagh, M., Halaseh, L., & AlAlawi, S. (2019). Correlates of resistin and retinol-binding protein 4 in metabolic syndrome patients with and without prediabetes. Hormone Molecular Biology and Clinical Investigation, 37(3), 20180051. https://doi.org/10.1515/hmbci-2018-0051

IBM Corp. (2015) IBM SPSS Statistics for Windows. (Version 23.0.). Armonk, NY: IBM Corp.

Jamaluddin, M. S., Weakley, S. M., Yao, Q., & Chen, C. (2012). Themed Section: Fat and Vascular Responsiveness Correspondence Resistin: functional roles and therapeutic considerations for cardiovascular disease. British Journal of Pharmacology, 165, 622–632. https://doi.org/10.1111/j.1476-5381.2011.01369.x

Krintus, M., Kuligowska-Prusińska, M., Laskowska, E., Janiszewska, E., & Kubica, J. (2015). The performance of triglyceride to high-density lipoprotein cholesterol ratio in acute coronary syndromes using a diagnostic decision tree. Medical Research Journal, 3, 13-19.

Maravilla D. M. A., Zermeño G. M. L., Zavaleta M. E. R., Montes V. V. A., Irecta N. C. A., Fajardo R. N. S., & Zavaleta M. S. A. (2022). Inflammation and atherogenic markers in patients with type 2 diabetes mellitus. Marcadores aterogénicos y de inflamación en pacientes con diabetes mellitus tipo 2. Clínica e Investigación en Arteriosclerosis: Publicación Oficial de la Sociedad Española de Arteriosclerosis, 34(3), 105–112. https://doi.org/10.1016/j.arteri.2021.03.006

Pourfarzam, M., Zadhoush, F., & Sadeghi, M. (2016). The difference in correlation between insulin resistance index and chronic inflammation in type 2 diabetes with and without metabolic syndrome. Advanced Biomedical Research, 5, 153. https://doi.org/10.4103/2277-9175.188489

Rašlová, K., Dobiášová, M., Hubáček, J. A., Bencová, D., Siváková, D., Danková, Z., Franeková, J., Jabor, A., Gašparovič, J., & Vohnout, B. (2011). Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population. Physiological research, 60(5), 785–795. https://doi.org/10.33549/physiolres.932069

Published

2023-10-31

How to Cite

Zavaleta Muñiz, S. A., Maravilla Domínguez , M. A., Martínez Sandoval, A., Muñoz Yañez, C., & Guangorena Gómez, J. O. (2023). Riesgo cardiovascular, adiposidad y marcadores aterogénicos e inflamatorios en pacientes con enfermedad metabólica. CISA, 5(5), 103–115. https://doi.org/10.58299/cisa.v5i5.41

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Section

Scientific articles: RESEARCH REPORTS