Riesgo cardiovascular, adiposidad y marcadores aterogénicos e inflamatorios en pacientes con enfermedad metabólica.
DOI:
https://doi.org/10.58299/cisa.v5i5.41Palabras clave:
Enfermedades metabólicas, índice aterogénico, adipocinas, índice plaquetas/linfocitos, índice neutrófilos/linfocito, riesgo cardiovascular, Metabolic diseases, atherogenic index, adipokines, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, cardiovascular risk.Resumen
Los desórdenes metabólicos se caracterizan por inflamación crónica de bajo grado. Diversos marcadores inflamatorios, aterogénicos y adipocinas se asocian con síndrome metabólico, incrementando la aterosclerosis y la morbi-mortalidad cardiovascular. Objetivo: describir el riesgo cardiovascular (RCV), la adiposidad, los marcadores inflamatorios y aterogénicos en pacientes mexicanos con enfermedad metabólica del Estado de Durango, México. En todos los participantes se realizó antropometría, determinación bioquímica y lipídica, biometría hemática y adipocinas séricas. Se calcularon adiposidad, índices aterogénicos e inflamatorios y RCV. La grasa visceral y corporal se clasificó como alta y muy alta, respectivamente; 88.3% tenían síndrome metabólico. El perfil lipídico, los marcadores bioquímicos, la adiponectina, el índice aterogénico y el RCV fueron mayores a mayor número de comorbilidades. Conclusión: las metas terapéuticas deben enfocarse enérgicamente a pacientes con mayor número de anormalidades metabólicas para disminuir su RCV y mortalidad.
Citas
Akbas, E. M., Demirtas, L., Ozcicek, A., Timuroglu, A., Bakirci, E. M., Hamur, H., Ozcicek, F., & Turkmen, K. (2014). Association of epicardial adipose tissue, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with diabetic nephropathy. International Journal of Clinical and Experimental Medicine, 7(7), 1794–1801. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132146/
Bawadi, H., Katkhouda, R., Tayyem, R., Kerkadi, A., Bou Raad, S., & Subih, H. (2019). Abdominal fat is directly associated with inflammation in persons with Type-2 Diabetes regardless of glycemic control - A Jordanian Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 12, 2411–2417. https://doi.org/10.2147/DMSO.S214426
Bazyar, H., Adibmanesh, A., Javid, A.Z., Maghsoumi-Norouzabad, L., Gravand, E., Alipour, M., & Sadeghi, N. (2019). The relationship between metabolic factors and anthropometric indices with periodontal status in type 2 diabetes mellitus patients with chronic periodontitis. Obesity Medicine, 16, 100138. https://doi.org/10.1016/j.obmed.2019.100138
Bohra A. (2015). Oral Aspects of Metabolic Disorders. Journal of Metabolic Syndrome, 4(3):1–4. https://doi.org/10.4172/2167-0943.1000178
Borges, M. D., Franca, E. L., Fujimori, M., Silva, S. M. C., de Marchi, P. G. F., Deluque, A. L., Honorio-Franca, A. C., & de Abreu, L. C. (2018). Relationship between Proinflammatory Cytokines/Chemokines and Adipokines in Serum of Young Adults with Obesity. Endocrine, Metabolic & Immune Disorders-Drug Targets, 18(3), 260–267. https://doi.org/org/10.2174/1871530318666180131094733
Choi, J., Joseph, L., & Pilote, L. (2013). Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, 14(3), 232–244. https://doi.org/10.1111/obr.12003
Choy, P. C., Siow, Y. L., Mymin, D., & O, K. (2004). Lipids and atherosclerosis. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire, 82(1), 212–224. https://doi.org/10.1139/o03-085
Ellulu, M. S., Patimah, I., Khaza'ai, H., Rahmat, A., & Abed, Y. (2017). Obesity and inflammation: the linking mechanism and the complications. Archives of medical science: AMS, 13(4), 851–863. https://doi.org/10.5114/aoms.2016.58928
Evia-Viscarra, M. L., Rodea-Montero, E. R., Apolinar-Jiménez, E., & Quintana-Vargas, S. (2013). Metabolic syndrome and its components among obese (BMI >=95th) Mexican adolescents. Endocrine Connections, 2(4), 208–215. https://doi.org/10.1530/EC-13-0057
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D'Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O'Donnell, C. J., Robinson, J. G., Schwartz, J. S., Shero, S. T., Smith, S. C., Sorlie, P., Stone, N. J., Wilson, P. W., Jordan, H. S., Nevo, L., Wnek, J. American College of Cardiology/American Heart Association Task Force on Practice Guidelines (2014). 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation, 129(25), S49–S73. https://doi.org/10.1161/01.cir.0000437741.48606.98
Horan, A. A., Albsoul-Younes, A., Kasabri, V., Suyagh, M., Halaseh, L., & AlAlawi, S. (2019). Correlates of resistin and retinol-binding protein 4 in metabolic syndrome patients with and without prediabetes. Hormone Molecular Biology and Clinical Investigation, 37(3), 20180051. https://doi.org/10.1515/hmbci-2018-0051
IBM Corp. (2015) IBM SPSS Statistics for Windows. (Version 23.0.). Armonk, NY: IBM Corp.
Jamaluddin, M. S., Weakley, S. M., Yao, Q., & Chen, C. (2012). Themed Section: Fat and Vascular Responsiveness Correspondence Resistin: functional roles and therapeutic considerations for cardiovascular disease. British Journal of Pharmacology, 165, 622–632. https://doi.org/10.1111/j.1476-5381.2011.01369.x
Krintus, M., Kuligowska-Prusińska, M., Laskowska, E., Janiszewska, E., & Kubica, J. (2015). The performance of triglyceride to high-density lipoprotein cholesterol ratio in acute coronary syndromes using a diagnostic decision tree. Medical Research Journal, 3, 13-19.
Maravilla D. M. A., Zermeño G. M. L., Zavaleta M. E. R., Montes V. V. A., Irecta N. C. A., Fajardo R. N. S., & Zavaleta M. S. A. (2022). Inflammation and atherogenic markers in patients with type 2 diabetes mellitus. Marcadores aterogénicos y de inflamación en pacientes con diabetes mellitus tipo 2. Clínica e Investigación en Arteriosclerosis: Publicación Oficial de la Sociedad Española de Arteriosclerosis, 34(3), 105–112. https://doi.org/10.1016/j.arteri.2021.03.006
Pourfarzam, M., Zadhoush, F., & Sadeghi, M. (2016). The difference in correlation between insulin resistance index and chronic inflammation in type 2 diabetes with and without metabolic syndrome. Advanced Biomedical Research, 5, 153. https://doi.org/10.4103/2277-9175.188489
Rašlová, K., Dobiášová, M., Hubáček, J. A., Bencová, D., Siváková, D., Danková, Z., Franeková, J., Jabor, A., Gašparovič, J., & Vohnout, B. (2011). Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population. Physiological research, 60(5), 785–795. https://doi.org/10.33549/physiolres.932069
